Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers: A Blind Randomized Controlled Trial.
Elmira
Esmaeilzadeh
Department of Internal Medicine, Division of Rheumatology, Shiraz University of Medical Sciences, Shiraz, Iran.
author
Mohammadali
Nazarinia
Geriatric Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
author
Saeedeh
Shenavandeh
Department of Internal Medicine, Division of Rheumatology, Shiraz University of Medical Sciences, Shiraz, Iran.
author
text
article
2019
eng
Aim: Assessing the effect of Diltiazem gel on scleroderma digital ulcers compared to Nitroglycerin ointment and placebo. Methods: A single blind randomized controlled trial was done on 90 scleroderma patients, randomly divided to three groups: one receiving Diltazem gel 2%, the other receiving Nitroglycerin ointment 2% and control one receiving Vaseline as placebo for 2 times per day for 8 weeks. The patients' demographic information and disease characteristics were summarized. The longest diameter of the ulcers was measured in 3 groups at the beginning and at the end of the study. The site of the ulcers and the number of new ones were, also, determined for each patient Results: The effect size of the ulcers, in each three groups, was significantly lower at the end of the survey (Diltiazem P
Rheumatology Research
Rheumatology Research
2476-5856
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no.
2019
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https://www.rheumres.org/article_70776_24ee05b5ab3bb66876e5b9991f0104e6.pdf
dx.doi.org/10.22631/rr.2019.69997.1065
Biomechanical properties of heel-pad and metatarsal head soft tissue and foot ulcers in patients with systemic sclerosis – a case control study
mandana
pourian
radiology department, Firouzgar hospital, Iran University of Medical Sciences, Tehran, Iran.
author
Iman
Mohseni
radiology department, Firouzgar hospital, Iran University of Medical Sciences, Tehran, Iran.
author
Maryam
Biglari Abhari
community medicine department, Firouzgar hospital, Iran University of Medical Sciences, Tehran, Iran.
author
Mahbod
Sianpanah
Internal medicine department, Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran.
author
text
article
2019
eng
Background: Systemic sclerosis is a chronic disease of connective tissue accompanied with increased risk of foot ulcers. Biomechanical indexes (soft tissue thickness and compressibility) could affect the risk of this phenomenon.Objective: The aim of this study was assessment of heel pad and first metatarsal head soft tissue thickness and compressibility index in scleroderma patients with and without foot ulcers and comparison with healthy individuals.Methods: Heel pad thickness in standing(loaded) and lying(unloaded) positions was measured in 40 scleroderma patients by means of lateral foot radiography. Compressibility index was measured as the ratio of loaded to unloaded thickness. Also, soft tissue thickness of first metatarsal head was measured with ultrasound. Results were compared with 40 healthy controls of matched age and body mass index.Results: Among 40 scleroderma patients (36 females, 4 males) with mean age of 45 (±12) years and mean body mass index of 25.5 (±4) and mean disease duration of 10 years (±9.6), 8 (20%) had foot ulcers. Heel pad thickness (p-value 0.03) and compressibility index (p-value 0.005) in the dominant side and both-sides metatarsal head soft tissue thickness (P-value
Rheumatology Research
Rheumatology Research
2476-5856
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2
no.
2019
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56
https://www.rheumres.org/article_82772_e1e764793cb39510cc2d64128ceb01cc.pdf
dx.doi.org/10.22631/rr.2019.69997.1066
Relation between Cytokines and Brucella Arthritis, Spondylitis, and Sacroiliitis
Nayyereh
Saadati
Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
author
Mandana
Khodashahi
Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
author
Bahram
Naghibzadeh
Mount Medical Center, Australia.
author
Rozita
Khodashahi
Department of Infectious Diseases, School of Medicine, Mashhad University of Medical Sciences,
Mashhad, Iran.
author
text
article
2019
eng
Background and Objectives: Cytokines are produced and secreted from various cells, including T cells. Cytokines play an effective role in the responses elicited by the immune system. As brucella infection cause is an intracellular aerobic rod, cellular immunity has a considerable effect on this disease. The aim of the present study was to evaluate the relation between cytokines and brucellosis arthritis, spondylitis, and sacroiliitis.Materials and Methods: This descriptive case-control study was carried in two tertiary hospitals in Mashhad, Iran in 2010. The study population consisted of a case group, including the patients with the diagnosis of brucella arthritis with lower back pain and a control group, including normal healthy participants. The brucellosis was investigated regarding the history, physical examinations, and serologic examinations. The interferon gamma (IFNγ), interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 10 (IL-10), and tumor necrosis factor alpha (TNFα) were measured in the serum samples of both groups using enzyme-linked immunosorbent assay technique. Results: The IL-10 had a significant difference in the brucella and control groups (P=0.02). However, IL-2, IL-4, and the TNFα were comparable between brucella and control groups (P=0.1). There was a significant difference between the IFNγ and brucella in the control group (P=0.05). Conclusion: The IFNγ and IL-10 levels were higher in brucella group than those in control group.
Rheumatology Research
Rheumatology Research
2476-5856
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2
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2019
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https://www.rheumres.org/article_81722_b54458905e0440bac70ee7bc4fd7f1a0.pdf
dx.doi.org/10.22631/rr.2019.69997.1067
Comparison of Sonographic Evaluation of the Median Nerve and Fourth Flexor Tendon Between Asymptomatic Subjects With and Without Diabetes
Seyed Hossein
Safiabadi-Tali
Department of Internal Medicine, Rasoul-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
author
fatemeh
shirani
Department of Internal Medicine, Rasoul-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
author
Anousheh
Haghighi
Department of Internal Medicine, Rasoul-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
author
Nahid
Kianmehr
Department of Internal Medicine, Rasoul-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
author
Ali
Javadzadeh
Department of Internal Medicine, Rasoul-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
author
Farrokh
Naderi
Department of Internal Medicine, Rasoul-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
author
Haleh
Chehrehgosha
Department of Internal Medicine, Rasoul-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
author
Majid
Khoshmirsafa
Department of Immunology, Iran University of Medical Sciences, Tehran, Iran.
author
text
article
2019
eng
Diabetes mellitus (DM) is a common metabolic disease associated with carpal tunnel syndrome (CTS) and tendinopathy. This study aims to assess the ultrasonographic (US) parameters of the flexor tendon and median nerve in asymptomatic subjects with diabetes in comparison with controls without diabetes. 22 DM and 22 non-DM subjects without any symptoms or manipulations in non-dominant hands and wrists were assessed. The ultrasound evaluation of the length, width, cross-sectional area and circumference of forth flexor tendon and the median nerve was performed in the two groups. There was no statistically significant difference of age (P = 0.473) , gender (P = 0.364) , wrist circumferences (P = 0.1921) between the two groups. This study showed no significant difference between the two groups in the median nerve length (P = 0.35), width (P = 0.17), cross-sectional circumference (P = 0.23) and cross-sectional area (P = 0.16). Also, comparing of the sonographic data of the fourth flexor tendon between the two groups presented no significant difference in the length (P = 0.68), width (P = 0.80), cross-sectional circumference (P = 0.70) and cross-sectional area (P = 0.80). In conclusion, our data showed that sonographic values of the median nerve and fourth flexor tendon in asymptomatic subjects with DM did not significantly differ with non-diabetics. These findings demonstrate that still more case studies and more evaluations are required to validate the applicability of ultrasonography in the prediction of carpal tunnel syndrome and tendinopathy in diabetic patients.
Rheumatology Research
Rheumatology Research
2476-5856
4
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2
no.
2019
63
69
https://www.rheumres.org/article_89914_93382ca694cb7ae464466ad9a5fa857e.pdf
dx.doi.org/10.22631/rr.2019.69997.1068
A Comparison between Avocado-Soybean Unsaponifiables and Celecoxib on Serum Levels of Cartilage Oligomeric Matrix Protein in Patients with Knee Osteoarthritis
Mohammadhassan
Jokar
School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
author
Hosein
Azadeh
School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
author
Zahra
Mirfeizi
School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
author
Jaleh
Shariati Sarabi
School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
author
Kamila
Hashemzadeh
School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
author
text
article
2019
eng
Background/objectives: Cartilage oligomeric matrix protein (COMP) as a marker of cartilage destruction. We aimed to compare the effect of a mixture of avocado-soybean unsaponifiables versus celecoxib on the serum level of COMP in patients with knee osteoarthritis.Methods: This was a randomized controlled trial and the patients with knee osteoarthritis were recruited from those who attended Imam Reza Hospital, Mashhad, Iran. The patients were divided randomly into two groups; Group 1 (n=30) received avocado+soybean mixture (300 mg daily) and group 2 (n=30) received celecoxib (200 mg/day) for 2 months. At the enrollment and then every month up to 2 months, the patients' venous blood samples were collected to measure serum COMP.Results: The total number of patients was 60 (male 38%, female 62%) with a mean age 56±7 years. Before treatment, the serum levels of COMP were 14.5±1.4 unit/liter (U/L) and 13.9±1.4 U/L in avocado+soybean mixture and celecoxib groups, respectively (P=0.052). After the first month the serum levels of COMP were 12.3±1.5 U/L and 12.8±1 U/L in avocado+soybean mixture and celecoxib groups, respectively (P
Rheumatology Research
Rheumatology Research
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2019
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https://www.rheumres.org/article_91469_bd060d53cf20eed95fc57aa6e49659af.pdf
dx.doi.org/10.22631/rr.2019.69997.1069
Refractory Ocular Behçet’s Disease; Outcome of Low Dose Infliximab
Nira
Ferdous
Modern One Stop Arthritis Care and Research Center®(MOAC&RC®), Dhaka.
Department of Medicine, MH Samorita Hospital and Medical College.
author
Md
Islam
1Modern One Stop Arthritis Care and Research Center®(MOAC&RC®), Dhaka.
Department of Rheumatology, Bangabandhu Sheikh Mujib Medical University
(BSMMU).
author
Farah
Rahman
1Modern One Stop Arthritis Care and Research Center®(MOAC&RC®), Dhaka.
author
Zahedur
Pannu
Bangladesh Eye Hospital, Dhaka.
author
Fahid
Nazrul
Modern One Stop Arthritis Care and Research Center®(MOAC&RC®), Dhaka.
author
Ashik
Zaman
Modern One Stop Arthritis Care and Research Center®(MOAC&RC®), Dhaka.
author
Johannes J
Rasker
Department of Psychology, Health and Technology, University of Twente, Enschede, the Netherlands.
author
text
article
2019
eng
A 40-year-old woman had been suffering of many symptoms of Behçet’s disease (BD) since her childhood without being diagnosed. She had recurrent mouth ulcers and from the age of 21 vulva ulcers followed by loss of vision due to central retinitis and later also ankle arthritis. At the age of 31, uveitis due to BD was diagnosed. The fact that BD is often not recognized in Bangladesh explains the marked delay in her diagnosis. The initial central retinitis responded well to oral glucocorticoids, azathioprine and cyclosporine, but in the course of time she became refractory to these agents. Considering her financial constraints, low dose Infliximab (3mg/kg) was used resulting in a remarkable but temporal improvement, she came in remission by using 5mg/kg regimen with increased interval time. We summarize the treatment options for ocular involvement in BD patientsConclusions: In countries like Bangladesh diagnosis of Behçet’s disease can be delayed. Early cooperation of dermatologists and eye surgeons with rheumatologists is necessary. Most cases of resistant ocular BD can nowadays be successfully treated with anti TNF-agents. Promising results are published with other biologics for refractory and multi-resistant cases.
Rheumatology Research
Rheumatology Research
2476-5856
4
v.
2
no.
2019
77
85
https://www.rheumres.org/article_86787_19bbd099e915b7373fe1fb8e85b73c83.pdf
dx.doi.org/10.22631/rr.2019.69997.1070