Rheumatology Research
Rheumatology Research
2476-5856
5
1
2020
03
01
Evaluation of Autoantibodies in patients with Systemic Sclerosis
1
6
EN
Marzieh
Asgari
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
marzieasgari91@gmail.com
Hoda
Kavosi
0000-0003-4762-6943
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Inflammation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
h-kavosi@sina.tums.ac.ir
Samaneh
Soltani
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
samaneh.soltani90@gmail.com
Amir
Ashraf-ganjouei
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
a.ganjuee@gmail.com
Ali
Javinani
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
javinaniali@gmail.com
Elham
Farhadi
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Inflammation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
farhadie@tums.ac.ir
Ashkan
Asadollahbaik
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
ashkan_baik@yahoo.com
Nooshin
Ahmadzadeh
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
nahmadzade@yahoo.com
Shiva
Poursani
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
shiva_ps65@yahoo.com
Ahmadreza
Jamshidi
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
jamshida@tums.ac.ir
Mahdi
Mahmoudi
0000-0002-8164-8831
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Inflammation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
mahmoudim@tums.ac.ir
Farhad
Gharibdost
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
gharibdoost@sina.tums.ac.ir
10.22631/rr.2020.69997.1083
<span class="fontstyle0">Systemic sclerosis is an autoimmune disease clinically characterized by vascular and immune dysfunction, leading to fibrosis<br />that can damage multiple organs. The presence of non-overlapping SSc-associated autoantibodies best presents the autoimmune<br />nature of systemic sclerosis. The primary purpose of this study was to investigate the autoantibody profile in Iranian patients<br />with systemic sclerosis. Sera from 481 patients with systemic sclerosis were collected from 2013 to 2016. Levels of anti-nuclear<br />antibodies (ANA) were quantitatively detected using the indirect immunofluorescence (IIF) method, and levels of specific<br />autoantibodies including anti-topoisomerase I antibody (ATA), anti-centromere antibody (ACA) and anti RNA polymerase III<br />antibody (anti-RNAP III) were determined qualitatively using the enzyme-linked immunosorbent assay (ELISA) technique.<br />Among all patients evaluated, a predominance of females (86.7%) was found, and 434 (90.2%) patients showed positive ANA<br />results by IIF. ANA was detected in 87.3% and 92.0% of limited cutaneous systemic sclerosis (lcSSc) and diffuse cutaneous<br />systemic sclerosis (dcSSc) patients, respectively, which was not significantly different. The frequency of anti-RNAP III, ACA,<br />and ATA was 5.19%, 6.09%, and 72.3%, respectively. Furthermore, anti-RNAP III, ATA, and ANA levels were correlated with<br />dcSSc, whereas ACA levels were correlated with lcSSc. It was confirmed that ATA expression is significantly higher in dcSSc<br />patients. This study had a lower frequency of ACA (6.09%) than most previous cohorts. The results demonstrated that the<br />clinical subtype of systemic sclerosis may correlate positively with the presence of specific autoantibodies.</span>
systemic sclerosis,autoantibody,Anti-Nuclear Antibody,anti-topoisomerase I antibody,anti-centromere antibody,anti RNA polymerase III antibody
https://www.rheumres.org/article_119815.html
https://www.rheumres.org/article_119815_92d57e8aa47c6f457a4c0f8fb0147a32.pdf
Rheumatology Research
Rheumatology Research
2476-5856
5
1
2020
03
01
Medication Adherence in Patients with Systemic Lupus Erythematosus : A Descriptive Study
7
12
EN
Sofia
Jami Alahmadi
0000-0003-4518-2330
School of Nursing & Midwifery, Tehran University of Medical Sciences, Tehran, Iran.
s.jami_735@hotmail.com
Seyedeh Tahereh
Faezi
0000-0002-5828-7556
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
s.t_faezi@yahoo.com
Mahdi
Mahmoudi
0000-0002-8164-8831
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
mahmoudim@tums.ac.ir
Leila
Sayadi
0000-0001-7613-3051
Nursing and Midwifery Care Research Center, School of Nursing& Midwifery, Tehran University of Medical Sciences, Tehran, Iran.
sayadi117@hotmail.com
10.22631/rr.2020.69997.1084
<span class="fontstyle0">Systemic lupus erythematosus is an autoimmune disease that affects several systems of the body. Due to the chronic nature of this<br />disease, non-adherence to a medication regimen can lead to deterioration by the disease and also misinterpretation of treatment<br />results. The aim of this study was to determine the medication adherence of patients with systemic lupus erythematosus.<br />In this descriptive study, medication adherence was investigated in 209 patients with SLE who were attending a lupus clinic in one<br />of the hospitals affiliated with Tehran University of Medical Sciences. The sample participants who fit inclusion criteria were<br />entered in the study by the convenience and continuous method. Then, they completed a demographic information form and the<br />eight-item Morisky medication adherence scale. Data were analyzed by SPSS software using descriptive statistics, chi-square, and<br />the ANOVA test.<br />The results showed that 18.7% of patients had high adherence to medication regimen, 94 patients (45.0%) had low adherence, and<br />76 patients (36.4%) had a moderate level of adherence to medication. There was no significant relationship between the demographic<br />and clinical variables of patients and their adherence to their medication.<br />It is necessary to take measures to increase medication adherence among these patients with systemic lupus erythematosus due to<br />their low and moderate medication adherence. It is also necessary that nurses and physicians in the clinic provide patient education<br />and heed this issue in medical and nursing programs.</span>
Systemic lupus erythematosus,Medications adherence,Non-adherence to medication
https://www.rheumres.org/article_118455.html
https://www.rheumres.org/article_118455_c5c4dd240fdc2560805000b84ef47b52.pdf
Rheumatology Research
Rheumatology Research
2476-5856
5
1
2020
03
01
Investigation of the frequency and clinical manifestations of Wegener vasculitis among other vasculitis patients in rheumatology ward of Vali-asr hospital during the past 10 years
13
17
EN
Rabeah
Rajabzadeh
Department of Rheumatology, Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
rabeah.rajabzadeh@gmail.com
Seyed Reza
Najafizadeh
Department of Rheumatology, Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
najafisr@tums.ac.ir
Shafieh
Movassaghi
Department of Rheumatology, Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
movaseghi@gmail.com
Sara
Jalali-Jivan
Department of Rheumatology, Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
sara.jalali.jivan@gmail.com
Abdolrahman
Rostamian
Department of Rheumatology, Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Rheumatology Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
arostamian@tums.ac.ir
10.22631/rr.2020.69997.1085
<span class="fontstyle0">Vasculitis is a rare disease and its prevalence varies according to age, race, time, and geographical location. The need for this study<br />is felt due to the fact that no study has been conducted in Iran to investigate the frequency, clinical, and laboratory symptoms of<br />vasculitis in the considerable population of vasculitis patients. The aim of this study was to evaluate the frequency and clinical<br />signs of granulomatosis with polyangiitis (GPA) patients who were admitted to the rheumatology ward in Valiasr Hospital, Tehran,<br />Iran, over the last 10 years.<br />In this study, all patients were evaluated with a possible diagnosis of vasculitis having been admitted to the rheumatology ward of<br />Valiasr Hospital over the past ten years. These GPA patients were evaluated for clinical, laboratory, radiological, and pathological<br />findings, as well as for outcome, mortality, and major complications.<br />Over the last 10 years, 223 vasculitis patients have been admitted to Valiasr Hospital and of these, 87% were primary vasculitis and<br />13% were secondary vasculitis. The highest frequency was related to GPA (21.52%) followed by Behcet's disease. GPA patients<br />were women and men at 52.08% and 47.91%, respectively. Upper and lower airway involvement and total ear, nose, and throat<br />(ENT) involvement was the most common clinical symptoms in GPA patients.<br />According to the findings of this study, GPA vasculitis was the most common type of vasculitis and ENT involvements were the<br />most common clinical symptoms in this patient. However, more studies are required to confirm these data in Iran.</span>
Wegener,Frequency,vasculitis,clinical symptoms
https://www.rheumres.org/article_118156.html
https://www.rheumres.org/article_118156_482c08c9ba63dc0edea36f43e66c4645.pdf
Rheumatology Research
Rheumatology Research
2476-5856
5
1
2020
03
01
Evaluation of clinical and Para clinical findings and treatment response in RA patients: Data from a single center RA registry
19
26
EN
Sara
Jalali-Jivan
Department of Rheumatology, Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
sara.jalali.jivan@gmail.com
Shafieh
Movassaghi
Department of Rheumatology, Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
movaseghi@gmail.com
Seyed Reza
Najafizadeh
Department of Rheumatology, Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
najafisr@tums.ac.ir
Abdolrahman
Rostamian
Department of Rheumatology, Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Rheumatology Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
arostamian@tums.ac.ir
Rabeah
Rajabzadeh
Department of Rheumatology, Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
rabeah.rajabzadeh@gmail.com
Hengameh
Babaei-Lakeh
school of Medicine, Islamic Azad University of Medical science, Tehran, Iran.
hengame.babaei@yahoo.com
Mahroo
Mohammad Hoseini
school of Medicine, Islamic Azad University of Medical science, Tehran, Iran.
mahroomohammadhosseini@gmail.com
Amirmasoud
Kazemzadeh-Houjaghan
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
amirm.kazemzadeh@gmail.com
Ghazal
Behzad
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
ghazalbehy73@gmail.com
10.22631/rr.2020.69997.1086
<span class="fontstyle0">Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease characterized by the inflammatory arthritis rheumatoid<br />factor (RF: An IgM produced against anti-immunoglobulin G) and anti-cyclic citrullinated peptide (anti-CCP) autoantibodies. In<br />the present study, the aim was to register RA patients in Imam Khomeini Hospital, Tehran, Iran.<br />The study population of this research was RA patients referred to the rheumatology clinic in 2019 at Imam Khomeini Hospital in<br />Tehran and had been diagnosed 5 years ago. Demographic, clinical, and laboratory information of patients at the beginning of<br />referral at 3 months, and 1, 2, 3, and 4 years after referral, were carefully recorded in each patient questionnaire.<br />In the first visit, 79 RA patients were examined and in the other 5 visits, 73, 52, 33, 20, 13 patients, respectively, were examined<br />totalling 270 visits. RF and anti-CCP were positive in 58.22% and 62.02% of patients, respectively. The mean age of patients<br />was 52.5±11.25 years. The results of the present study showed that the mean morning stiffness, DAS, arthritis, arthralgia, ESR, and<br />CRP decreased from the second visit through the following five visits which indicated disease control.<br />Clinical and laboratory data showed considerable disease control, however, relapse of disease was seen due to drug discontinuation.<br />Registering the disease makes it possible to record the necessary information of each patient, including demographic, clinical, and<br />paraclinical findings as well as consultations, and gives the physician accurate access to patient information and unnecessary<br />duplication of paraclinical examinations.</span>
Rheumatoid arthritis,Registry
https://www.rheumres.org/article_118155.html
https://www.rheumres.org/article_118155_c4fcf903448fa6507555d104a4e0af72.pdf
Rheumatology Research
Rheumatology Research
2476-5856
5
1
2020
03
01
Investigating Adherence to Medication in Patients Diagnosed with Systemic Lupus Erythematosus: A Cross-Sectional Study in Iran
27
32
EN
Omid
Eslami
GastroenterologyandHepatologyResearchCenter, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
kouroshkabir2574@yahoo.com
Amir
Hossein
Norooznezhad
0000-0002-9987-7093
Inflammation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
norooznezhad@gmail.com
Shafieh
Movassaghi
Rheumatology Research center, Vali-Asr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Tehran, Iran.
movassaghi@gmail.com
Neda
Naderi
Nephrology Research Center, Center of Excellence in Nephrology, Tehran University of Medical Sciences, Tehran, Iran.
naderi_neda@yahoo.com
Abdolrahman
Rostamian
Rheumatology Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
arostamian@sina.tums.ac.ir
Taraneh
Dormohammadi Toosi
Rheumatology Research center, Vali-Asr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Tehran, Iran.
Rheumatology Division, University of San Diego, CA, USA.
taraneh_dormohammadi@yahoo.com
10.22631/rr.2020.69997.1087
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with an unknown aetiology. Although there is no definite treatment for this disease using proper prescribed medications, mortality and morbidity ratios could be decreased. The present study attempted to investigate adherence to medical treatment in patients suffering from SLE and to evaluate the related factors which influence adherence in order to improve patients’ prognoses. In this cross-sectional study, 132 patients with SLE who referred to the rheumatology clinic of Imam Khomeini Hospital (Tehran, Iran) over the period of 2012-2013 were<br />examined using a questionnaire. The applied questionnaire included two parts; the first part pertained to adherence to medication treatments (CQR: compliance questionnaire rheumatology), and the second part was related to the factors involved in adherence to medication treatments. The obtained data were analyzed using the Chi-Square test and processed by SPSS16.0 software.<br />In this research, the mean adherence to drug treatment was calculated to be 72.48%. Among the variables of age, marital status, salary, education, distance from the clinic (accessibility), disease duration, level of patient activity, main medications consumed, and side effects, the only significant association was found between adherence level and lack of side effects due to SLE (p <0.05). One hypothesis regarding the cause of appropriate adherence to medical treatment in the studied group could be the hope<br />of never experiencing side effects; however, more investigation is needed to prove this theory.
Systemic lupus erythematosus,Treatment Adherence,Drug side effect
https://www.rheumres.org/article_119853.html
https://www.rheumres.org/article_119853_78702f5a560f9dd647ee6a14f32ccebb.pdf
Rheumatology Research
Rheumatology Research
2476-5856
5
1
2020
03
01
A woman with a bamboo spine in the thoracic vertebra and normal sacroiliac joint; a 5-years undiagnosed ankylosing spondylitis: Case report and literature review
33
38
EN
Masoud
Mortezazadeh
0000-0003-3585-9379
Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
masoudmm1990@yahoo.com
Farzan
Vahedifard
0000-0002-0803-7831
Iran University of Medical Sciences, Tehran, Iran.
farzanvahedi@yahoo.com
Sajjad
Ahmadi-Renani
Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
sajjadahmadi1993@gmail.com
Ahmad
Salimzadeh
Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
salimzad@sina.tums.ac.ir
10.22631/rr.2020.69997.1088
<span class="fontstyle0">Ankylosing spondylitis (AS) is a chronic inflammatory disease that causes deterioration in the function of the spine and peripheral<br />joints. In addition to history and examination, imaging is important in diagnosing this disease. Pelvic X-rays in particular may show<br />pseudo widening, erosion, and sclerosis sacroiliac joint. Spinal X-rays may also identify syndesmophytes. In more advanced stages,<br />the spine may also be involved, forming a specific type of disease called “bamboo spine”. The New York criteria, which includes<br />radiologic and clinical criteria, are used to diagnose AS. The distribution of involvement in joints and bones in AS varies, but<br />classically, it is ascending from the sacroiliac joint, lumbar, and thoracic region.<br />Herein, we report a case of AS that was undiagnosed for 5 years. Despite the normal appearance of the sacroiliac joint, severe<br />involvement of the spinal column in the thoracic region known as “bamboo spine” was observed. The time order of bone<br />involvement in this patient is contrary to what is usually seen.<br />Based on the New York criteria for AS, the case under discussion is not included in the AS definition; however, the patient had<br />clinical symptoms of AS, bamboo spine, and showed a dramatic response to treatment of AS.<br />Heeding the course of the AS as well as the clinical signs and imaging results of various areas (heart, lumbar spine, and sacroiliac<br />joint) will help physicians diagnose AS accurately and in a timely manner. Also, the radiologic manifestation of a rheumatologic<br />disease may occur without any predictable order.</span>
ankylosing spondylitis,bamboo spine,bone involvement,pathophysiology
https://www.rheumres.org/article_113437.html
https://www.rheumres.org/article_113437_89102adff20118cf11c1a87e9cd7dd10.pdf