TY - JOUR ID - 149448 TI - Immune-mediated necrotizing myositis following SARS-Cov-2: A case report JO - Rheumatology Research JA - RR LA - en SN - AU - Shadmanfar, Soraya AU - Alishiri, Golamhossein AU - Jafari, Ramezan AU - Davoudi-Monfared, Esmat AD - Health Research Center, Life style institute, Department of Rheumatology, Baqiyatallah University of Medical Sciences, Tehran, Iran. AD - Chemical Injuries Research Center, Department of Rheumatology, Baqiyatallah University of Medical Sciences, Tehran, Iran. AD - Health Research Center, Department of Radiology, Baqiyatallah University of Medical Sciences, Tehran, Iran. AD - Health Management Research Center, Department of community medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran. Y1 - 2021 PY - 2021 VL - 6 IS - 3 SP - 145 EP - 149 KW - COVID-19 KW - Myositis KW - Necrotizing KW - SARS-CoV-2 DO - 10.32592/RR.2021.6.3.145 N2 - A 56-year-old woman who had been coughing for 7 weeks was brought to the hospital on April 21, following the sensation of weakness in her lower extremities, then in her upper extremities, and a gradual increase in weakness. Reverse transcriptionpolymerase chain reaction (RT-PCR) testing of coronavirus disease 2019 (COVID-19) was found to be positive. COVID-19 IgG was also positive.Computed tomography (CT) scan of the chest showed patchy ground-glass opacities in the lungs. Muscle enzymes and aldolase were elevated. Muscle MRI showed defined hyperintensity and edema in proximal muscles. Immune mediated necrotizing myositis (IMNM) was recommended in this patient that may have developed following SARS-Cov-2. Treatment was begun with methylprednisolone pulse and intravenous immune globulin (IVIG). Following the start of treatment, the patient's dyspnea and muscle weakness improved. Although IMNM is a rare condition, especially in SARS-Cov-2, it is rapidly debilitating. Physicians need to be more aware of the clinical and paraclinical features and therapeutic approach of IMNM. UR - https://www.rheumres.org/article_149448.html L1 - https://www.rheumres.org/article_149448_670dc8fc40f720b34432f0b57444466f.pdf ER -