Document Type: Original Article

Authors

1 Serveis Medics Penedès. Department of Orthopaedics

2 Department of Radiology, Serveis Medics Penedes 08720 Vilafranca del Penedes BARCELONA

Abstract

Objectives. To test the hypotheses that surgical joint denervation produces a significant reduction of synovitis possibly through a depletion of intra-articular inflammatory neuropeptides such as substance P and CGRP.
Methods. Retrospective analysis of sonographic Doppler images was used to assess the synovitic changes in 16 first carpometacarpal joints of 15 patients (mean age 63.31 +/- 8.20) that had undergone surgical denervation to treat osteoarthritic pain. We used a paired t-test to compare Doppler sonographic image differences between two time-points, pre-operative and at least six months after the operation in order to evaluate variations in articular synovitis.
Results. A significant difference (p

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