Since mid-December of 2019, an outbreak of pneumonia has been spread from Wuhan City, Hubei province, China, as a viral pneumonia. After virus identification and isolation, the pathogen for this pneumonia was originally called 2019 novel coronavirus (2019-nCoV). 2019-nCoV has been associated with progressive cytokine storm leading to a hyper-inflammatory state that this state associated with respiratory failure. We hereby reported a known case of Rheumatoid arthritis, Hypertension and Coronary artery bypass graft that confirmed 2019-nCoV and he was associated with progressive cytokine storm leading to respiratory failure. After corticosteroid administration, respiratory failure and extremely high levels of IL6 responded dramatically to pulse-doses of Methylprednisolone. We concluded that pulse-doses of Corticosteroids can be effective in controlling and relieving cytokine storms and related respiratory failure.