Document Type : Original Article


1 Division of Rheumatology, Allergy and Immunology, University of California at San Diego, United States of America

2 Inflammation Research Center, Tehran University of Medical Sciences, Tehran, Iran

3 Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

4 Rheumatology Research center, Tehran University of Medical Sciences, Tehran, Iran, Vali-Asr Hospital, Imam Khomeini Hospital Complex, Tehran, Iran

5 Nephrology Research Center, Center of Excellence in Nephrology, Tehran University of Medical Sciences, Tehran, Iran


Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with an unknown etiology. Although there is no definite treatment for this disease but using proper prescribed medications, mortality and morbidity ratios could be decreased. Methods: The present study has attempted to investigate the adherence to medical treatment in patients suffering from SLE and also evaluate the related factors which influenced on their adherence in order to improve patients’ prognosis. In this cross-sectional study, 132 patients with SLE referred to the rheumatology clinic of Imam Khomeini hospital (Tehran, Iran) over the period of 2012-2013 were examined using a questionnaire. The applied questionnaire included two parts; the first part pertains to adherence to medication treatments (CQR: compliance questionnaire rheumatology) and the second part was related to the factors involved in adherence to medication treatments. The obtained data was analyzed using Chi-Square test and processed by SPSS16.0 software. Results: In this research, the mean adherence to drug treatment was calculated as 72.48%. Among the variables of age, marital status, salary, education, distance from the clinic (accessibility), the duration of disease, the level of patient’s activity, main medications consumed and side effects, there was only a significant association between adherence level and the lack of side effects due to SLE (p


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