Kidney involvement is a major cause of death and disability in patients with systemic lupus erythematosus (SLE). Early and
accurate determination of the type of involvement is essential in choosing the appropriate treatment for these patients. The
current study aimed to determine whether laboratory findings are consistent with kidney biopsy for biopsy classification.
This descriptive analytic cross-sectional study was performed on 17 patients with SLE admitted to rheumatology and nephrology
departments. All patients underwent renal biopsy and received appropriate treatment according to the reported pathology. Data
analysis was performed using SPSS software version 25. The participants comprised 14 females and 3 males with a mean age
of 32.23±11.12 years. The findings of this study showed that mean serum C3 and 24-hour urine protein concentrations were
significantly different between the four studied groups according to the type of kidney pathology (p =0.042, p =0.041;
respectively). No significant relationship was found between pathological findings and clinical signs, demographic information,
and other laboratory findings (p >0.05). Based on the findings of the present study, it can be concluded that renal biopsy is the
most accurate method available for the diagnosis and classification of lupus nephritis. Nonetheless, renal biopsy has limitations
including side effects, the need for an experienced pathologist, and suboptimality in some cases; renal biopsy was suboptimal
in three cases of the current study. Therefore, noninvasive faster methods with high efficacy should be sought.