Document Type : Original Article

Authors

1 Department of Rheumatology, Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

2 Department of Rheumatology, Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

3 Department of General Surgery, School of Medicine, Nephrology Research Center Imam Khomeini Hospital, Tehran University of Medical Sciences Tehran, Iran.

Abstract

Background and objective: Kidney involvement is one of the major causes of death and disability in patients with systemic lupus erythematosus (SLE). Early and accurate determination of the type of involvement is essential in choosing the appropriate treatment for these patients. The aim of this study was to determine whether laboratory findings are consistent with kidney biopsy for biopsy classification.
Methods and material: This descriptive analytic cross-sectional study was performed on 17 patients with SLE admitted to rheumatology and nephrology departments. All patients underwent renal biopsy and received appropriate treatment according to the reported pathology. Data analysis was performed using SPSS software version 25.
Results: There were 14 females and 3 males with mean age of 32.23±11.12 years. The findings of this study showed that the mean serum C3 and 24-hour urine protein concentration were significantly different between the four groups according to the type of kidney pathology. It was also found that there was no significant relationship between pathological findings and clinical signs, demographic information and other laboratory findings.
Conclusion: Based on the findings of the present study, it can be concluded that renal biopsy is the most accurate method available for the diagnosis and classification of lupus nephritis. But, regard to the limitations of renal biopsy include side effects, need to experienced pathologist and sub optimality in some cases (renal biopsy was suboptimal in three cases of the current study), we should be looking for noninvasive faster methods with high efficacy.

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