Systemic sclerosis (SSc) is an autoimmune rheumatic disorder characterized by vascular damages, sclerotic changes in the skin, and multi-system involvement of internal organs. Digital ischemic lesions, nailfold capillary abnormalities, and secondary Raynaud’s phenomenon are Common manifestations of microvascular injuries. Recent findings have revealed that macrovascular involvement in Systemic sclerosis is more prevalent than previously believed. There have been reports of large vessel involvement such as the ulnar, femoral, carotid, renal, and pulmonary arteries. We herein report a case of a young woman with progressive systemic sclerosis who complained of lower limb pain, dysphagia secondary to esophageal dysfunction, and urinary incontinence. She had symptoms of Raynaud’s phenomenon, skin sclerosis, sclerodactyly, digital pitting ulcers, nailfold capillary abnormalities, and digital ischemia. On special examination, the anti-centromere antibody was detected. She developed bilateral popliteal artery occlusion as a complication of SSc.