BACKGROUND: Behçet’s disease is a chronic multisystem disorder. The principal pathological finding in BD is vasculitis, which may involve vessels of different sizes. Concurrence of small and large vessel involvement in BD patients is undetermined. This study aims to evaluate small vessel involvement in BD patients with large vessel involvement.
METHODS: 35 BD patients with large vessel involvement (cases) and 35 BD patients without large vessel involvement (controls) were included. For evaluation of small vessel involvement, capillaroscopy was done for all patients. Capillaroscopic findings were compared between two groups.
RESULTS: According to the capillaroscopic findings, all of our BD patients had small vessel involvement.
The most abnormality was tortuosity (87.1%), followed by enlarged loops (58.6%) and avascular areas (51.4%). Capillaroscopy findings were not statistically different between the case and the control groups. There was a significant association between micro bleeding and the history of erythema nodosum (p=0.015), tortuosity and the history of skin aphthosis (p= 0.015), architectural derangement and the history of uveitis (p=0.029), the number of avascular areas and active oral aphthosis (p= 0.021), and architectural derangement and increased ESR (p=0.011).
CONCLUSION: There was no difference in nailfold capillary involvement between BD patients with and without large vessel involvement. However, some capillaroscopic features were associated with some disease manifestations.