Esmaeilzadeh, E., Nazarinia, M., Shenavandeh, S. (2018). Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers: A Blind Randomized Controlled Trial.. Rheumatology Research, (), -.
Elmira Esmaeilzadeh; Mohammadali Nazarinia; Saeedeh Shenavandeh. "Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers: A Blind Randomized Controlled Trial.". Rheumatology Research, , , 2018, -.
Esmaeilzadeh, E., Nazarinia, M., Shenavandeh, S. (2018). 'Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers: A Blind Randomized Controlled Trial.', Rheumatology Research, (), pp. -.
Esmaeilzadeh, E., Nazarinia, M., Shenavandeh, S. Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers: A Blind Randomized Controlled Trial.. Rheumatology Research, 2018; (): -.
Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers: A Blind Randomized Controlled Trial.
Articles in Press, Accepted Manuscript , Available Online from 05 October 2018
1Department of Internal Medicine, Division of Rheumatology, Shiraz University of Medical Sciences, Shiraz, Iran.
2Geriatric Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract
Aim: Assessing the effect of Diltiazem gel on scleroderma digital ulcers compared to Nitroglycerin ointment and placebo. Methods: A single blind randomized controlled trial was done on 90 scleroderma patients, randomly divided to three groups: one receiving Diltazem gel 2%, the other receiving Nitroglycerin ointment 2% and control one receiving Vaseline as placebo for 2 times per day for 8 weeks. The patients' demographic information and disease characteristics were summarized. The longest diameter of the ulcers was measured in 3 groups at the beginning and at the end of the study. The site of the ulcers and the number of new ones were, also, determined for each patient Results: The effect size of the ulcers, in each three groups, was significantly lower at the end of the survey (Diltiazem P