Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers: A Blind Randomized Controlled Trial.

	Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers: A Blind Randomized Controlled Trial.
Articles in Press, Accepted Manuscript , Available Online from 05 October 2018
Document Type: Original Article
Authors
Elmira Esmaeilzadeh ¹; Mohammadali Nazarinia ²; Saeedeh Shenavandeh¹
¹Department of Internal Medicine, Division of Rheumatology, Shiraz University of Medical Sciences, Shiraz, Iran.
²Geriatric Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract
Aim: Assessing the effect of Diltiazem gel on scleroderma digital ulcers compared to Nitroglycerin ointment and placebo. Methods: A single blind randomized controlled trial was done on 90 scleroderma patients, randomly divided to three groups: one receiving Diltazem gel 2%, the other receiving Nitroglycerin ointment 2% and control one receiving Vaseline as placebo for 2 times per day for 8 weeks. The patients' demographic information and disease characteristics were summarized. The longest diameter of the ulcers was measured in 3 groups at the beginning and at the end of the study. The site of the ulcers and the number of new ones were, also, determined for each patient Results: The effect size of the ulcers, in each three groups, was significantly lower at the end of the survey (Diltiazem P
Keywords
Keywords: Scleroderma; Diltiazem; Nitroglycerin; Ulcer
Main Subjects
Sysytemic Sclerosis


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