Document Type: Original Article
1Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, Iran
Rheumatic Disease Research Center (RDRC), Ghaem Medical Center, MUMS, Mashhad, Iran
Department of Infectious Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Background and Objectives: Cytokines are produced and secreted from various cells, including T cells. Cytokines play an effective role in the responses elicited by the immune system. As brucella infection cause is an intracellular aerobic rod, cellular immunity has a considerable effect on this disease. The aim of the present study was to evaluate the relation between cytokines and brucellosis arthritis, spondylitis, and sacroiliitis.
Materials and Methods: This descriptive case-control study was carried in two tertiary hospitals in Mashhad, Iran in 2010. The study population consisted of a case group, including the patients with the diagnosis of brucella arthritis with lower back pain and a control group, including normal healthy participants. The brucellosis was investigated regarding the history, physical examinations, and serologic examinations. The interferon gamma (IFNγ), interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 10 (IL-10), and tumor necrosis factor alpha (TNFα) were measured in the serum samples of both groups using enzyme-linked immunosorbent assay technique.
Results: The IL-10 had a significant difference in the brucella and control groups (P=0.02). However, IL-2, IL-4, and the TNFα were comparable between brucella and control groups (P=0.1). There was a significant difference between the IFNγ and brucella in the control group (P=0.05).
Conclusion: The IFNγ and IL-10 levels were higher in brucella group than those in control group.