TY - JOUR ID - 91469 TI - A Comparison between Avocado-Soybean Unsaponifiables and Celecoxib on Serum Levels of Cartilage Oligomeric Matrix Protein in Patients with Knee Osteoarthritis JO - Rheumatology Research JA - RR LA - en SN - AU - Jokar, Mohammadhassan AU - Azadeh, Hosein AU - Mirfeizi, Zahra AU - Shariati Sarabi, Jaleh AU - Hashemzadeh, Kamila AD - School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Y1 - 2019 PY - 2019 VL - 4 IS - 2 SP - 71 EP - 75 KW - Cartilage oligomeric matrix protein KW - Avocado KW - soy KW - Celecoxib KW - Knee osteoarthritis DO - 10.22631/rr.2019.69997.1069 N2 - Background/objectives: Cartilage oligomeric matrix protein (COMP) as a marker of cartilage destruction. We aimed to compare the effect of a mixture of avocado-soybean unsaponifiables versus celecoxib on the serum level of COMP in patients with knee osteoarthritis.Methods: This was a randomized controlled trial and the patients with knee osteoarthritis were recruited from those who attended Imam Reza Hospital, Mashhad, Iran. The patients were divided randomly into two groups; Group 1 (n=30) received avocado+soybean mixture (300 mg daily) and group 2 (n=30) received celecoxib (200 mg/day) for 2 months. At the enrollment and then every month up to 2 months, the patients' venous blood samples were collected to measure serum COMP.Results: The total number of patients was 60 (male 38%, female 62%) with a mean age 56±7 years. Before treatment, the serum levels of COMP were 14.5±1.4 unit/liter (U/L) and 13.9±1.4 U/L in avocado+soybean mixture and celecoxib groups, respectively (P=0.052). After the first month the serum levels of COMP were 12.3±1.5 U/L and 12.8±1 U/L in avocado+soybean mixture and celecoxib groups, respectively (P UR - https://www.rheumres.org/article_91469.html L1 - https://www.rheumres.org/article_91469_bd060d53cf20eed95fc57aa6e49659af.pdf ER -