Document Type : Original Article
1 Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2 Rheumatology Research Centre (RRC), Golestan University of Medical Sciences, Gorgan, Iran
3 Immunology Research Center, Inflammation and inflammatory diseases Division, Mashhad University of Medical Sciences, Mashhad, Iran
Background and Objective: It has been proposed that anti-annexin V as a novel proposed mechanism for the increased prevalence of atherosclerosis among patients with Systemic Lupus Erythematosus (SLE). Here we aimed to compare anti-annexin V levels between SLE patients and healthy controls and to determine the correlation of anti-annexin with various cardiovascular risk factors.
Materials and Method: Sixty patients with SLE and 30 healthy sex and age matched persons included in the current cross sectional study that was selected from outpatient Rheumatology clinics in the city of Mashhad-Iran. Anti-annexin V and the other parameters including cardiovascular risk factors
(age, smoking, blood pressure, diabetes mellitus, lipoproteins levels, previous history of documented or clinically suspected atherosclerosis, obesity, premature ovarian failure, high sensitive C-reactive protein, vascular cell adhesion protein 1 and homocystein) measured using enzyme linked immuno-assay.
Results: Anti-annexin V had a significant positive correlation with LDL levels in the SLE group (p=0.03). Anti-annexin V levels were not significantly different between the two groups (p=0.40).
Conclusion: We could not show the role of anti-annexin V as a predictor of atherosclerosis risk in patients with lupus under study.