Document Type : Review


1 Rheumatology Research Center, Tehran University of Medical Sciences

2 Internal Medicine Department, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran


Systemic sclerosis (Scleroderma/ SSc) is a rare, connective autoimmune multisystem disease with wide-reaching consequences. SSc is recognized by the presence of serum autoantibodies, and fibroproliferative changes of the microvasculature which in turn results in too much accumulation of collagen fibers in the skin and internal organs. Gastrointestinal (GI) involvement has a high prevalence among SSc patients (in over 90% of cases). Altered GI function and subsequently nutritional disorders are common outcomes of SSc, affecting the quality of life (QoL) and may carry an associated rate of morbidity and mortality. Besides, disease-related malnourishment is considered to have a detrimental effect on clinical outcomes. There is little information on dietary advice for SSc patients and as GI complaints are risk factors for bad nutritional status, perceptive assessment seems to be necessitated. Considering that SSc pathogenesis is yet to be explored, recent investigations aimed to evaluate the effect of diet, in terms of triggering or altering the course of the disease. The present review aimed to discuss current knowledge relating to the effect of nutrition on SSc pathogenesis.


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