Document Type : Review

Authors

1 Department of Physical Medicine and Rehabilitation Room No. 600/B, Cabin Block, BSMMU, Shahbag, Dhaka-1000, Bangladesh

2 Department of Physical Medicine and Rehabilitation Room No. 500, Floor 5, Brahmanbaria Medical College Hospital. Brahmanbaria-3400, Bangladesh

3 Department of Obstetrics and Gynaecology, Room No. 106, Dhaka medical college Hospital, Dhaka-1205, Bangladesh

4 Room No. 137, Block-C, Department of Physical Medicine and Rehabilitation, BSMMU, Shahbag, Dhaka-1000, Bangladesh

5 Department of Physical Medicine and Rehabilitation, Room No. 137, Block-C, BSMMU, Shahbag, Dhaka-1000, Bangladesh

6 Department of Public Health and Informatics, Room No. 209, Block-B, BSMMU, Dhaka-1000, Bangladesh

7 Department of Epidemiology, Room No. 201, NIPSOM, Dhaka, Bangladesh

8 Department of Public Health and Informatics, Room No. 208 Dhaka-1000, Bangladesh

9 Professor and Chairman, Department of Public Health and Informatics, room No. 206 Dhaka-1000, Bangladesh

10 Department of Rheumatology (Online Program), University of South Wales CF37 1DL Pontypridd Cardiff, UK.

11 Professor at the Department of psychology and communication of health, Faculty behavioral sciences and philosophy University, Twente, Enschede, Netherlands

Abstract

Introduction: Coronavirus disease (COVID-19) started its journey from Wuhan, China and gradually became a pandemic. COVID-19 often affects the respiratory system, but symptoms may include fatigue, myalgia, arthralgia, arthritis, spine-, and bone pain as presenting complaints. In the present systematic search and review, we aim to highlight the musculoskeletal manifestations during COVID-19.
Methods: Using PubMed Central and Google Scholar search engines, we used as key words “muscle pain”, “joint pain”, “body ache”, “fatigue”, in Covid-19 patients.
Results: After screening, a total of 76 articles were included following inclusion criteria dated between January 1 and July 1, 2020. All articles were published in English comprising 36558 COVID-19 cases. In cross sectional studies, fatigue was found in 55%, myalgia in 26%, and arthralgia in 20%, respectively. In cohort studies, fatigue was found in 35%, myalgia in 15%, and arthralgia in 5%, respectively. Sporadic case reports also mention back pain, bone pain, myositis and arthritis as presenting symptoms of COVID-19.
Discussion: Fatigue was the most frequent musculoskeletal (MSK) manifestion of COVID-19 followed by myalgia and joint pain. The frequency of the different MSK manifestations in COVID-19 may vary widely among different geographic regions.
Conclusions: MSK like fatigue, myalgia and arthralgia are frequent symptoms in COVID-19 patients and may vary in different countries.

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