Document Type : Original Article


1 Rheumatic Diseases Research Center (RDRC), Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Nuclear Medicine Department, Razavi Hospital, Imam Reza International University, Mashhad, Iran.

3 Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.


Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that causes chronic synovial inflammation. Reactor-produced
β-particle emitting radionuclides is a new therapeutic strategy in the management of RA. This study was conducted in 2019
and analyzed the toxicity and feasibility of
188Re-tin colloid injection, Three-Phase Positive Bone Scan, and Refractory Knee
Pain. Ten patients with RA were administered radiosynovectomy with
188Re-tin colloid. The main complications after the
intervention were assessed and compared with patients’ pre-intervention condition. Patients showed alleviation of pain,
tenderness, and morning stiffness after the administration of radiosynovectomy. Only one RA patient received a corticosteroid
injection; the other 6 patients did not need a corticosteroid injection after radiosynovectomy. Intra-articular
188Re-tin colloid
injection seems to be an effective treatment modality for refractory knee joint pain in rheumatoid arthritis patients. Thus, it is
suggested as a safe and effective strategy to apply.


Main Subjects