Amyloidosis is a rare condition that develops when an irregular protein accumulates in the organs called amyloid that interferes with their normal function. In conjunction with other disorders such as rheumatoid arthritis (RA) and psoriasis, amyloidosis may occur due to a chronic inflammatory process. With the treatment of the underlying disease, amyloidosis can be treated. Certain forms of amyloidosis can lead to life-threatening organ failure. In fact, it can involve heart, kidneys and Nervous system. As the signs and symptoms can imitate those of more common illnesses, amyloidosis is sometimes ignored. Early diagnosis may help minimize additional injury to organs. Precise diagnosis is important because, based on the individual case, care differs greatly. We aim to present a patient referred to our hospital with some manifestations of RA and psoriatic arthritis (PsA) that were compatible with Amyloidosis. also we discuss treatment in this patient.