Document Type : Review


1 1. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran 2. Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran

2 Department of Rheumatology, Loghman Hakim Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran



Rheumatoid arthritis (RA) is a polygenic autoimmune disease characterized by systemic inflammation and disability of  joints. Early diagnosis and treatment could prevent diseases in RA patients from becoming severe. miRNAs are small, non-coding RNA that regulate the post-transcriptional level of gene expression. miRNAs play important roles in gene expression and pathogenicity of autoimmune diseasesas well as RA. Properly using miRNAs regulation potential and detecting different expression patterns andtheir functions could facilitate and manage effective therapeuticinterventions in RA patients. Herein, we discuss miRNAs as a therapeutic agent in RA patients.


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