Document Type : Case Report
Authors
1 Department of Rheumatology, Loghman Hakim Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran
2 Department of Adult Rheumatology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Department of Adult Rheumatology, School of Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, tehran, iran.
Abstract
Extra-nodal natural killer/T cell lymphoma (EN-NK/T) is a highly uncommon aggressive mature T or NK-cell lymphoma with a high fatality rate. It has a propensity for infiltrating tissues and spreading to the eye. EN-NK/T-NT is marked by polymorphic clinical characteristics, which can make diagnosis difficult and cause delayed management. This report details a 63-year-old Iranian woman who presented initially with left ocular involvement of unknown cause. Ethmoidal sinusitis, upper nasal obstruction, right proptosis, dacryocystitis, and pulmonary nodules were later developed as her disease progressed. Biopsies of the orbit, ethmoidal sinus and pulmonary nodules were significant for EN-NK/T cell lymphoma. The patient developed Covid-19 and was treated for it. Due to the progressive lymphoma, chemotherapy was initiated after recovery from Covid-19. After starting the first course of chemotherapy, the patient's condition deteriorated with the possibility of pulmonary embolism. The state of the patient deteriorated rapidly, and she expired on AUG 2021. This case highlights the diagnostic difficulty of EN-NK/T cell lymphoma, demonstrating its rarity and ability to mimic other diseases.
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