Hypercalcemia is a rare manifestation in systemic lupus erythematosus patients.
In this case report, a thirty-five-year-old woman with a 3-year-old history of lupus was reported. Our case had symptoms of lupus flair, including joint pain, hair loss, photosensitivity, a high level of calcium and creatinine, and lymphadenopathy. In her brain MRI, intracranial haemorrhage was detected.
Given her high serum level of calcium and phosphorus, reduced PTH, and normal level of vitamin D, her hypercalcemia was attributed to the presence of stimulating parathyroid hormone (PTH) receptor auto-antibody.
Regarding the findings of this study, it is suggested to consider systematic lupus erythematosus (SLE) as a rare but possible cause of severe hypercalcemia.